PRI ANTIBODY HUMANIZATION TECHNOLOGY – Contract Research Service
Protein Design Labs’ (PDL) technology:
Former PDL team members using algorithms developed by PDL work closely with PRI to design best-in-class humanized antibodies.
Has your humanization technology been used for clinically evaluated products?
Yes, many times.
IP situation / Freedom to Operate
Worldwide FTO; patents expired in 2014
$75,000 (USD) in silico
$125,000 (USD) cell lines – 50% upfront
More than 200 mAbs have been humanized using the PDL technology. 15 out of the ~40 FDA-approved mAbs have been humanized using this method.
What are typical timelines for humanization?
In silico analysis and sequences are available @ 1 month.
Any other considerations?
Sequences are routinely checked for potential immunogenicity and manufacturability.
Larix Bioscience LLC is a PRI spin-out company with the revolutionary AMS technology to identify high producing cell lines. A high producing cell line (40-60 pg/cell/d) can be provided for an additional $250,000 (USD).
Deliverables: What will we receive? e.g. sequence data, report etc.
Sequences and a report will be delivered upon completion of the project. Commercial cell lines suitable for master cell banking are provided if the AMS technology is used.
James W. Larrick MD PhD