PRI ANTIBODY HUMANIZATION TECHNOLOGY – Contract Research Service

Technology/Methodology
Protein Design Labs’ (PDL) technology:
Former PDL team members using algorithms developed by PDL work closely with PRI to design best-in-class humanized antibodies.

Has your humanization technology been used for clinically evaluated products?
Yes, many times.

IP situation / Freedom to Operate
Worldwide FTO; patents expired in 2014

Terms
$75,000 (USD) in silico
$125,000 (USD) cell lines – 50% upfront

(Clinical) validation
More than 200 mAbs have been humanized using the PDL technology. 15 out of the ~40 FDA-approved mAbs have been humanized using this method.

Timelines
What are typical timelines for humanization?
4-5 months
In silico analysis and sequences are available @ 1 month.

Any other considerations?
Sequences are routinely checked for potential immunogenicity and manufacturability.
Larix Bioscience LLC is a PRI spin-out company with the revolutionary AMS technology to identify high producing cell lines. A high producing cell line (40-60 pg/cell/d) can be provided for an additional $250,000 (USD).
See Larixbioscience.com

Deliverables: What will we receive? e.g. sequence data, report etc.
Sequences and a report will be delivered upon completion of the project. Commercial cell lines suitable for master cell banking are provided if the AMS technology is used.

Contact
James W. Larrick MD PhD
jwlarrick@gmail.com