ALL

July 2, 2015

4

Telomerase redux: ready for prime time?

By panoweb | ALL, Cancer, Health, Rejuvenation, Telomerase | No Comments

Author: JW Larrick, AR Mendelsohn. Rejuvenation Res. 2015 Apr;18(2):185-7. By maintaining genome integrity, controlling cell proliferation, and regulating tissue homeostasis, telomerase plays a critical role in the pathology of aging and cancer. Telomerase is composed…

July 2, 2015

0

Systemic factors mediate reversible age-associated brain dysfunction.

By panoweb | Aging, ALL, Brain, Health | No Comments

Author: JW Larrick, AR Mendelsohn. Rejuvenation Res. 2014 Dec;17(6):525-8. Brain function declines in aging mammals. Recent work has identified dysregulation of key blood-borne factors whose altered expression during aging diminishes brain function in mice. Increased...

July 2, 2015

0

Prolonged fasting/refeeding promotes hematopoietic stem cell regeneration and rejuvenation.

By panoweb | ALL, Fasting, Health, Stem Cell | No Comments

Author: JW Larrick, AR Mendelsohn. Rejuvenation Res. 2014 Aug;17(4):385-9. The sensitivity of hematopoietic stem cells (HSCs) to toxic effects of cancer chemotherapy is one of the major roadblocks in cancer therapy. Moreover, the loss of…

July 2, 2015

2

Paradoxical effects of antioxidants on cancer.

By panoweb | ALL, Antioxidants, Cancer | No Comments

Author: JW Larrick, AR Mendelsohn. Rejuvenation Res. 2014 Jun;17(3):306-11. Antioxidants have had a checkered history concerning their reported ability to prevent or treat cancer. Early studies that showed ascorbate had benefit in cancer were followed...

July 2, 2015

1

Partial reversal of skeletal muscle aging by restoration of normal NAD⁺ levels.

By panoweb | Aging, ALL, Restoration, Skeletal Muscle | No Comments

Author: JW Larrick, AR Mendelsohn. Rejuvenation Res. 2014 Feb;17(1):62-9. That some aging-associated phenotypes may be reversible is an emerging theme in contemporary aging research. Gomes et al. report that age-associated oxidative phosphorylation (OXPHOS) defects in...

July 2, 2015

1

Sleep facilitates clearance of metabolites from the brain: glymphatic function in aging and neurodegenerative diseases.

By panoweb | Aging, ALL, Brain, Neurodegenerative Diseases, Rejuvenation, Sleep | No Comments

Author: JW Larrick, AR Mendelsohn. Rejuvenation Res. 2013 Dec;16(6):518-23. Decline of cognition and increasing risk of neurodegenerative diseases are major problems associated with aging in humans. Of particular importance is how the brain removes potentially...

July 2, 2015

2

Trade-offs between anti-aging dietary supplementation and exercise.

By panoweb | Aging, ALL, Dietary Supplementation, Exercise, Health | No Comments

Author: JW Larrick, AR Mendelsohn. Rejuvenation Res. 2013 Oct;16(5):419-26. In otherwise healthy adults, moderate aerobic exercise extends life span and likely health span by 2-6 years. Exercise improves blood sugar regulation, and resistance exercise increases...

July 2, 2015

1

Rejuvenation of aging hearts.

By panoweb | Aging, ALL, Heart, Rejuvenation | No Comments

Author: JW Larrick, AR Mendelsohn. Rejuvenation Res. 2013 Aug;16(4):330-2. Specific subtle changes in regulation or activity of factors that maintain homeostasis and cell differentiation may play significant roles in mammalian aging. Drift resulting from reaching...

July 2, 2015

0

Dietary modification of the microbiome affects risk for cardiovascular disease.

By panoweb | ALL, Cardiovascular Disease, Dietary Modification | No Comments

Author: JW Larrick, AR Mendelsohn. Rejuvenation Res. 2013 Jun;16(3):241-4. The incidence of cardiovascular disease (CVD) increases with age and is associated with some syndromes that exhibit aspects of premature aging, such as progeria. Various factors…

July 2, 2015

0

Rejuvenation of adult stem cells: is age-associated dysfunction epigenetic?

By panoweb | Aging, ALL, Rejuvenation, Stem Cell | No Comments

Author: JW Larrick, AR Mendelsohn. Rejuvenation Res. 2013 Apr;16(2):152-7. The dysfunctional changes of aging are generally believed to be irreversible due to the accumulation of molecular and cellular damage within an organism’s somatic cells and…

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