Author: JW Larrick, AR Mendelsohn. Rejuvenation Res. 2015 Apr;18(2):185-7. By maintaining genome integrity, controlling cell proliferation, and regulating tissue homeostasis, telomerase plays a critical role in the pathology of aging and cancer. Telomerase is composed…
Author: JW Larrick, AR Mendelsohn. Rejuvenation Res. 2014 Aug;17(4):385-9. The sensitivity of hematopoietic stem cells (HSCs) to toxic effects of cancer chemotherapy is one of the major roadblocks in cancer therapy. Moreover, the loss of…
Author: JW Larrick, AR Mendelsohn. Rejuvenation Res. 2013 Jun;16(3):241-4. The incidence of cardiovascular disease (CVD) increases with age and is associated with some syndromes that exhibit aspects of premature aging, such as progeria. Various factors…
Author: JW Larrick, AR Mendelsohn. Rejuvenation Res. 2013 Apr;16(2):152-7. The dysfunctional changes of aging are generally believed to be irreversible due to the accumulation of molecular and cellular damage within an organism’s somatic cells and…