Brain

Systemic factors mediate reversible age-associated brain dysfunction.

By panowebAging, ALL, Brain, HealthNo Comments

Author: JW Larrick, AR Mendelsohn. Rejuvenation Res. 2014 Dec;17(6):525-8. Brain function declines in aging mammals. Recent work has identified dysregulation of key blood-borne factors whose altered expression during aging diminishes brain function in mice. Increased...

July 2, 2015

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Sleep facilitates clearance of metabolites from the brain: glymphatic function in aging and neurodegenerative diseases.

By panowebAging, ALL, Brain, Neurodegenerative Diseases, Rejuvenation, SleepNo Comments

Author: JW Larrick, AR Mendelsohn. Rejuvenation Res. 2013 Dec;16(6):518-23. Decline of cognition and increasing risk of neurodegenerative diseases are major problems associated with aging in humans. Of particular importance is how the brain removes potentially...

July 2, 2015

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Epigenetic-mediated decline in synaptic plasticity during aging.

By panowebAging, ALL, Brain, MemoryNo Comments

Author: JW Larrick, AR Mendelsohn. Rejuvenation Res. 2012 Feb;15(1):98-101. Cognitive decline observed in aging mammals is associated with decreased long-term synaptic plasticity, especially long-term potentiation (LTP). Recent work has uncovered a connection between LTP, histone…

July 2, 2015

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Overcoming the aging systemic milieu to restore neural stem cell function.

By panowebAging, ALL, BrainNo Comments

Author: JW Larrick, AR Mendelsohn. Rejuvenation Res. 2011 Dec;14(6):681-4. As mammals age, the rate of neurogenesis in the brain declines with a concomitant reduction in cognitive ability. Recent data suggest that plasma-borne factors are responsible…

July 2, 2015

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Reversing age-related decline in working memory.

By panowebALL, Brain, Health, MemoryNo Comments

Author: JW Larrick, AR Mendelsohn. Rejuvenation Res. 2011 Oct;14(5):557-9. Higher cognitive functions, such as working memory and the ability to focus attention, decline as people age. Recently, it has been reported that decline in working memory...

July 2, 2015

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Systemic factors mediate reversible age-associated brain dysfunction.

Sleep facilitates clearance of metabolites from the brain: glymphatic function in aging and neurodegenerative diseases.

Epigenetic-mediated decline in synaptic plasticity during aging.

Overcoming the aging systemic milieu to restore neural stem cell function.

Reversing age-related decline in working memory.

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